Isoform-specific Ras signaling is growth factor dependent

HRAS, NRAS, and KRAS isoforms are almost identical proteins that are ubiquitously expressed and activate a common set of effectors. In vivo studies have revealed that they are not biologically redundant; however, the isoform specificity of Ras signaling remains poorly understood. Using a novel panel...

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Veröffentlicht in:Mol Biol Cell
Hauptverfasser: Hood, Fiona E., Klinger, Bertram, Newlaczyl, Anna U., Sieber, Anja, Dorel, Mathurin, Oliver, Simon P., Coulson, Judy M., Blüthgen, Nils, Prior, Ian A.
Format: Artigo
Sprache:Inglês
Veröffentlicht: The American Society for Cell Biology 2019
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Articles
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6724511/
https://ncbi.nlm.nih.gov/pubmed/30785867
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1091/mbc.E18-10-0676
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