A multicenter randomized, double-blind, placebo-controlled pilot study to assess the efficacy and safety of riociguat in systemic sclerosis-associated digital ulcers

BACKGROUND: To determine the effect of riociguat, an oral, selective soluble guanylate cyclase stimulator, on the net digital ulcer (DU) burden in systemic sclerosis (SSc). METHODS: Participants with SSc-related active or painful indeterminate DUs were recruited in a multicenter, double-blind, rando...

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Detalhes bibliográficos
Publicado no:Arthritis Res Ther
Main Authors: Nagaraja, Vivek, Spino, Cathie, Bush, Erica, Tsou, Pei-Suen, Domsic, Robyn T., Lafyatis, Robert, Frech, Tracy, Gordon, Jessica K., Steen, Virginia D., Khanna, Dinesh
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2019
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6724329/
https://ncbi.nlm.nih.gov/pubmed/31481106
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13075-019-1979-7
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