Abatacept in Early Diffuse Cutaneous Systemic Sclerosis – Results of a Phase 2 Investigator-Initiated, Multicenter, Double-Blind Randomized Placebo-Controlled Trial

OBJECTIVES: T cells play a key role in the pathogenesis of early systemic sclerosis. This study assessed the safety and efficacy of abatacept in patients with diffuse cutaneous systemic sclerosis (dcSSc). METHODS: A 12-month, randomized, double-blind, placebo-controlled trial with participants rando...

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Udgivet i:Arthritis Rheumatol
Main Authors: Khanna, Dinesh, Spino, Cathie, Johnson, Sindhu, Chung, Lorinda, Whitfield, Michael, Denton, Christopher P., Berrocal, Veronica, Jennifer, Franks, Mehta, Bhaven, Molitor, Jerry, Steen, Virginia D., Lafyatis, Robert, Simms, Robert W., Gill, Anna, Kafaja, Suzanne, Frech, Tracy M., Hsu, Vivien, Domsic, Robyn T., Pope, Janet E., Gordon, Jessica K., Mayes, Maureen D., Schiopu, Elena, Young, Amber, Sandorfi, Nora, Park, Jane, Hant, Faye N., Bernstein, Elana J., Chatterjee, Soumya, Castelino, Flavia V., Ajam, Ali, Wang, Yue, Wood, Tammara, Allanore, Yannick, Matucci-Cerinic, Marco, Distler, Oliver, Singer, Ora, Bush, Erica, Fox, David, Furst, Daniel E.
Format: Artigo
Sprog:Inglês
Udgivet: 2019
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6935399/
https://ncbi.nlm.nih.gov/pubmed/31342624
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/art.41055
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