Thimet Oligopeptidase (EC 3.4.24.15) Key Functions Suggested by Knockout Mice Phenotype Characterization

Thimet oligopeptidase (THOP1) is thought to be involved in neuropeptide metabolism, antigen presentation, neurodegeneration, and cancer. Herein, the generation of THOP1 C57BL/6 knockout mice (THOP1(−/−)) is described showing that they are viable, have estrus cycle, fertility, and a number of puppies...

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Publicat a:Biomolecules
Autors principals: dos Santos, Nilton B., Franco, Roseane D., Camarini, Rosana, Munhoz, Carolina D., Eichler, Rosangela A. S., Gewehr, Mayara C. F., Reckziegel, Patricia, Llanos, Ricardo P., Dale, Camila S., da Silva, Victoria R. O., Borges, Vanessa F., Lima, Braulio H. F., Cunha, Fernando Q., Visniauskas, Bruna, Chagas, Jair R., Tufik, Sergio, Peres, Fernanda F., Abilio, Vanessa C., Florio, Jorge C., Iwai, Leo K., Rioli, Vanessa, Presoto, Benedito C., Guimaraes, Alessander O., Pesquero, Joao B., Bader, Michael, Castro, Leandro M., Ferro, Emer S.
Format: Artigo
Idioma:Inglês
Publicat: MDPI 2019
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6722639/
https://ncbi.nlm.nih.gov/pubmed/31431000
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/biom9080382
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