Unlike the Escherichia coli counterpart, archaeal RNase HII cannot process ribose monophosphate abasic sites and oxidized ribonucleotides embedded in DNA

The presence of ribonucleoside monophosphates (rNMPs) in nuclear DNA decreases genome stability. To ensure survival despite rNMP insertions, cells have evolved a complex network of DNA repair mechanisms, in which the ribonucleotide excision repair pathway, initiated by type 2 RNase H (RNase HII/2),...

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Bibliografische gegevens
Gepubliceerd in:J Biol Chem
Hoofdauteurs: Malfatti, Matilde Clarissa, Henneke, Ghislaine, Balachander, Sathya, Koh, Kyung Duk, Newnam, Gary, Uehara, Ryo, Crouch, Robert J., Storici, Francesca, Tell, Gianluca
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: American Society for Biochemistry and Molecular Biology 2019
Onderwerpen:
DNA and Chromosomes
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6721941/
https://ncbi.nlm.nih.gov/pubmed/31300556
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA119.009493
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