Abasic and oxidized ribonucleotides embedded in DNA are processed by human APE1 and not by RNase H2

Ribonucleoside 5′-monophosphates (rNMPs) are the most common non-standard nucleotides found in DNA of eukaryotic cells, with over 100 million rNMPs transiently incorporated in the mammalian genome per cell cycle. Human ribonuclease (RNase) H2 is the principal enzyme able to cleave rNMPs in DNA. Whet...

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Bibliographic Details
Published in:Nucleic Acids Res
Main Authors: Malfatti, Matilde Clarissa, Balachander, Sathya, Antoniali, Giulia, Koh, Kyung Duk, Saint-Pierre, Christine, Gasparutto, Didier, Chon, Hyongi, Crouch, Robert J., Storici, Francesca, Tell, Gianluca
Format: Artigo
Language:Inglês
Published: Oxford University Press 2017
Subjects:
Genome Integrity, Repair and Replication
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5737539/
https://ncbi.nlm.nih.gov/pubmed/28977421
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkx723
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