Adaptation of hepatitis C virus to interferon lambda polymorphism across multiple viral genotypes

Genetic polymorphism in the interferon lambda (IFN-λ) region is associated with spontaneous clearance of hepatitis C virus (HCV) infection and response to interferon-based treatment. Here, we evaluate associations between IFN-λ polymorphism and HCV variation in 8729 patients (Europeans 77%, Asians 1...

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Vydáno v:eLife
Hlavní autoři: Chaturvedi, Nimisha, Svarovskaia, Evguenia S, Mo, Hongmei, Osinusi, Anu O, Brainard, Diana M, Subramanian, G Mani, McHutchison, John G, Zeuzem, Stefan, Fellay, Jacques
Médium: Artigo
Jazyk:Inglês
Vydáno: eLife Sciences Publications, Ltd 2019
Témata:
Genetics and Genomics
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6721370/
https://ncbi.nlm.nih.gov/pubmed/31478832
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.42542
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