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Allele-Specific Real-Time PCR System for Detection of Subpopulations of Genotype 1a and 1b Hepatitis C NS5B Y448H Mutant Viruses in Clinical Samples

The Y448H mutation in NS5B has been selected by GS-9190 as well as several benzothiadiazine hepatitis C virus (HCV) polymerase inhibitors in vitro and in vivo. However, the level and the evolution kinetics of this resistance mutation prior to and during treatment are poorly understood. In this study...

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書誌詳細
主要な著者: Bae, Andrew S., Ku, Karin S., Miller, Michael D., Mo, Hongmei, Svarovskaia, Evguenia S.
フォーマット: Artigo
言語:Inglês
出版事項: American Society for Microbiology 2011
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC3165570/
https://ncbi.nlm.nih.gov/pubmed/21715590
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JCM.00274-11
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