Clumps of Mesenchymal Stem Cell/Extracellular Matrix Complexes Generated with Xeno-Free Conditions Facilitate Bone Regeneration via Direct and Indirect Osteogenesis

Three-dimensional clumps of mesenchymal stem cell (MSC)/extracellular matrix (ECM) complexes (C-MSCs) consist of cells and self-produced ECM. We demonstrated previously that C-MSCs can be transplanted into bone defect regions with no artificial scaffold to induce bone regeneration. To apply C-MSCs i...

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Bibliographic Details
Published in:Int J Mol Sci
Main Authors: Motoike, Souta, Kajiya, Mikihito, Komatsu, Nao, Horikoshi, Susumu, Ogawa, Tomoya, Sone, Hisakatsu, Matsuda, Shinji, Ouhara, Kazuhisa, Iwata, Tomoyuki, Mizuno, Noriyoshi, Fujita, Tsuyoshi, Ikeya, Makoto, Kurihara, Hidemi
Format: Artigo
Language:Inglês
Published: MDPI 2019
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6720767/
https://ncbi.nlm.nih.gov/pubmed/31443173
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms20163970
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