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Combination of a Rapidly Penetrating Agonist and a Slowly Penetrating Antagonist Affords Agonist Action of Limited Duration at the Cellular Level

The capsaicin receptor TRPV1 (transient receptor potential vanilloid 1) has been an object of intense interest for pharmacological development on account of its critical role in nociception. In the course of structure activity analysis, it has become apparent that TRPV1 ligands may vary dramatically...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Biomol Ther (Seoul)
Prif Awduron: Pearce, Larry V., Ann, Jihyae, Blumberg, Peter M., Lee, Jeewoo
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: The Korean Society of Applied Pharmacology 2019
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC6720535/
https://ncbi.nlm.nih.gov/pubmed/31302951
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4062/biomolther.2019.013
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