Synthesis and biological evaluation of novel N-(piperazin-1-yl)alkyl-1H-dibenzo[a,c]carbazole derivatives of dehydroabietic acid as potential MEK inhibitors

In this paper, a series of novel 1H-dibenzo[a,c]carbazole derivatives of dehydroabietic acid bearing different N-(piperazin-1-yl)alkyl side chains were designed, synthesised and evaluated for their in vitro anticancer activities against three human hepatocarcinoma cell lines (SMMC-7721, HepG2 and He...

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Vydáno v:J Enzyme Inhib Med Chem
Hlavní autoři: Chen, Hao, Qiao, Chao, Miao, Ting-Ting, Li, A-Liang, Wang, Wen-Yan, Gu, Wen
Médium: Artigo
Jazyk:Inglês
Vydáno: Taylor & Francis 2019
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Research Paper
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6720511/
https://ncbi.nlm.nih.gov/pubmed/31448648
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/14756366.2019.1655407
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