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Alkylated Piperazines and Piperazine-Azole Hybrids as Antifungal Agents

The extensive use of fluconazole (FLC) and other azole drugs has caused the emergence and rise of azole-resistant fungi. The fungistatic nature of FLC in combination with toxicity concerns have resulted in an increased demand for new azole antifungal agents. Herein, we report the synthesis and antif...

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Publicat a:J Med Chem
Autors principals: Chandrika, Nishad Thamban, Shrestha, Sanjib K., Ngo, Huy X., Tsodikov, Oleg V., Howard, Kaitlind C., Garneau-Tsodikova, Sylvie
Format: Artigo
Idioma:Inglês
Publicat: 2017
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5976239/
https://ncbi.nlm.nih.gov/pubmed/29256601
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jmedchem.7b01138
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