Transient Receptor Potential V Channels Are Essential for Glucose Sensing by Aldolase and AMPK

Fructose-1,6-bisphosphate (FBP) aldolase links sensing of declining glucose availability to AMPK activation via the lysosomal pathway. However, how aldolase transmits lack of occupancy by FBP to AMPK activation remains unclear. Here, we show that FBP-unoccupied aldolase interacts with and inhibits e...

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Bibliografiset tiedot
Julkaisussa:Cell Metab
Päätekijät: Li, Mengqi, Zhang, Chen-Song, Zong, Yue, Feng, Jin-Wei, Ma, Teng, Hu, Meiqin, Lin, Zhizhong, Li, Xiaotong, Xie, Changchuan, Wu, Yaying, Jiang, Dong, Li, Ying, Zhang, Cixiong, Tian, Xiao, Wang, Wen, Yang, Yanyan, Chen, Jie, Cui, Jiwen, Wu, Yu-Qing, Chen, Xin, Liu, Qing-Feng, Wu, Jianfeng, Lin, Shu-Yong, Ye, Zhiyun, Liu, Ying, Piao, Hai-Long, Yu, Li, Zhou, Zhuan, Xie, Xiao-Song, Hardie, D. Grahame, Lin, Sheng-Cai
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: Cell Press 2019
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Article
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC6720459/
https://ncbi.nlm.nih.gov/pubmed/31204282
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cmet.2019.05.018
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