Transient Receptor Potential V Channels Are Essential for Glucose Sensing by Aldolase and AMPK

Fructose-1,6-bisphosphate (FBP) aldolase links sensing of declining glucose availability to AMPK activation via the lysosomal pathway. However, how aldolase transmits lack of occupancy by FBP to AMPK activation remains unclear. Here, we show that FBP-unoccupied aldolase interacts with and inhibits e...

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Publicado no:Cell Metab
Main Authors: Li, Mengqi, Zhang, Chen-Song, Zong, Yue, Feng, Jin-Wei, Ma, Teng, Hu, Meiqin, Lin, Zhizhong, Li, Xiaotong, Xie, Changchuan, Wu, Yaying, Jiang, Dong, Li, Ying, Zhang, Cixiong, Tian, Xiao, Wang, Wen, Yang, Yanyan, Chen, Jie, Cui, Jiwen, Wu, Yu-Qing, Chen, Xin, Liu, Qing-Feng, Wu, Jianfeng, Lin, Shu-Yong, Ye, Zhiyun, Liu, Ying, Piao, Hai-Long, Yu, Li, Zhou, Zhuan, Xie, Xiao-Song, Hardie, D. Grahame, Lin, Sheng-Cai
Formato: Artigo
Idioma:Inglês
Publicado em: Cell Press 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6720459/
https://ncbi.nlm.nih.gov/pubmed/31204282
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cmet.2019.05.018
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