Hierarchical activation of compartmentalized pools of AMPK depends on severity of nutrient or energy stress

AMPK, a master regulator of metabolic homeostasis, is activated by both AMP-dependent and AMP-independent mechanisms. The conditions under which these different mechanisms operate, and their biological implications are unclear. Here, we show that, depending on the degree of elevation of cellular AMP...

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Enregistré dans:
Détails bibliographiques
Publié dans:Cell Res
Auteurs principaux: Zong, Yue, Zhang, Chen-Song, Li, Mengqi, Wang, Wen, Wang, Zhichao, Hawley, Simon A., Ma, Teng, Feng, Jin-Wei, Tian, Xiao, Qi, Qu, Wu, Yu-Qing, Zhang, Cixiong, Ye, Zhiyun, Lin, Shu-Yong, Piao, Hai-Long, Hardie, D. Grahame, Lin, Sheng-Cai
Format: Artigo
Langue:Inglês
Publié: Nature Publishing Group UK 2019
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6796943/
https://ncbi.nlm.nih.gov/pubmed/30948787
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41422-019-0163-6
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