Pharmacological Activation of Sirt1 Ameliorates Cisplatin-Induced Acute Kidney Injury by Suppressing Apoptosis, Oxidative Stress, and Inflammation in Mice

Sirtuin 1 (Sirt1) is an essential modulator of cellular metabolism and has pleiotropic effects. It was recently reported that Sirt1 overexpression in kidney tubule ameliorates cisplatin-induced acute kidney injury (AKI). However, whether pharmacological activation of Sirt1 also has a beneficial effe...

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Detalhes bibliográficos
Publicado no:Antioxidants (Basel)
Main Authors: Kim, Jung-Yeon, Jo, Jungmin, Kim, Kiryeong, An, Hyun-Jin, Gwon, Mi-Gyeong, Gu, Hyemin, Kim, Hyun-Ju, Yang, A Young, Kim, Sung-Woo, Jeon, Eon Ju, Park, Jae-Hyung, Leem, Jaechan, Park, Kwan-Kyu
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6720310/
https://ncbi.nlm.nih.gov/pubmed/31431003
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/antiox8080322
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