PNPLA3 I148M Variant Impairs Liver X Receptor Signaling and Cholesterol Homeostasis in Human Hepatic Stellate Cells

The patatin‐like phospholipase domain‐containing protein 3 (PNPLA3) I148M variant predisposes to hepatic steatosis and progression to advanced liver injury with development of fibrosis, cirrhosis, and cancer. Hepatic stellate cells (HSCs) drive the wound healing response to chronic injury, and lack...

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Enregistré dans:
Détails bibliographiques
Publié dans:Hepatol Commun
Auteurs principaux: Bruschi, Francesca Virginia, Claudel, Thierry, Tardelli, Matteo, Starlinger, Patrick, Marra, Fabio, Trauner, Michael
Format: Artigo
Langue:Inglês
Publié: John Wiley and Sons Inc. 2019
Sujets:
Original Articles
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6719741/
https://ncbi.nlm.nih.gov/pubmed/31497741
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/hep4.1395
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