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PNPLA3 I148M Variant Impairs Liver X Receptor Signaling and Cholesterol Homeostasis in Human Hepatic Stellate Cells

The patatin‐like phospholipase domain‐containing protein 3 (PNPLA3) I148M variant predisposes to hepatic steatosis and progression to advanced liver injury with development of fibrosis, cirrhosis, and cancer. Hepatic stellate cells (HSCs) drive the wound healing response to chronic injury, and lack...

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Detalhes bibliográficos
Publicado no:Hepatol Commun
Main Authors: Bruschi, Francesca Virginia, Claudel, Thierry, Tardelli, Matteo, Starlinger, Patrick, Marra, Fabio, Trauner, Michael
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2019
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6719741/
https://ncbi.nlm.nih.gov/pubmed/31497741
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/hep4.1395
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