PNPLA3 I148M Variant Impairs Liver X Receptor Signaling and Cholesterol Homeostasis in Human Hepatic Stellate Cells

The patatin‐like phospholipase domain‐containing protein 3 (PNPLA3) I148M variant predisposes to hepatic steatosis and progression to advanced liver injury with development of fibrosis, cirrhosis, and cancer. Hepatic stellate cells (HSCs) drive the wound healing response to chronic injury, and lack...

Full description

Saved in:
Bibliographic Details
Published in:Hepatol Commun
Main Authors: Bruschi, Francesca Virginia, Claudel, Thierry, Tardelli, Matteo, Starlinger, Patrick, Marra, Fabio, Trauner, Michael
Format: Artigo
Language:Inglês
Published: John Wiley and Sons Inc. 2019
Subjects:
Original Articles
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6719741/
https://ncbi.nlm.nih.gov/pubmed/31497741
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/hep4.1395
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items