BIK ubiquitination by the E3 ligase Cul5-ASB11 determines cell fate during cellular stress

The BH3-only pro-apoptotic protein BIK is regulated by the ubiquitin–proteasome system. However, the mechanism of this regulation and its physiological functions remain elusive. Here, we identify Cul5-ASB11 as the E3 ligase targeting BIK for ubiquitination and degradation. ER stress leads to the act...

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Bibliographische Detailangaben
Veröffentlicht in:J Cell Biol
Hauptverfasser: Chen, Fei-Yun, Huang, Min-Yu, Lin, Yu-Min, Ho, Chi-Huan, Lin, Shu-Yu, Chen, Hsin-Yi, Hung, Mien-Chie, Chen, Ruey-Hwa
Format: Artigo
Sprache:Inglês
Veröffentlicht: Rockefeller University Press 2019
Schlagworte:
Research Articles
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6719446/
https://ncbi.nlm.nih.gov/pubmed/31387940
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.201901156
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