Glucose stimulates somatostatin secretion in pancreatic δ-cells by cAMP-dependent intracellular Ca(2+) release

Somatostatin secretion from pancreatic islet δ-cells is stimulated by elevated glucose levels, but the underlying mechanisms have only partially been elucidated. Here we show that glucose-induced somatostatin secretion (GISS) involves both membrane potential-dependent and -independent pathways. Alth...

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Bibliographic Details
Published in:J Gen Physiol
Main Authors: Denwood, Geoffrey, Tarasov, Andrei, Salehi, Albert, Vergari, Elisa, Ramracheya, Reshma, Takahashi, Harumi, Nikolaev, Viacheslav O., Seino, Susumo, Gribble, Fiona, Reimann, Frank, Rorsman, Patrik, Zhang, Quan
Format: Artigo
Language:Inglês
Published: Rockefeller University Press 2019
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Research Articles
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6719402/
https://ncbi.nlm.nih.gov/pubmed/31358556
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1085/jgp.201912351
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