Enhanced nuclear protein export in premature aging and rescue of the progeria phenotype by modulation of CRM1 activity

The study of Hutchinson–Gilford progeria syndrome (HGPS) has provided important clues to decipher mechanisms underlying aging. Progerin, a mutant lamin A, disrupts nuclear envelope structure/function, with further impairment of multiple processes that culminate in senescence. Here, we demonstrate th...

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Publicat a:Aging Cell
Autors principals: García‐Aguirre, Ian, Alamillo‐Iniesta, Alma, Rodríguez‐Pérez, Ruth, Vélez‐Aguilera, Griselda, Amaro‐Encarnación, Elianeth, Jiménez‐Gutiérrez, Elizabeth, Vásquez‐Limeta, Alejandra, Samuel Laredo‐Cisneros, Marco, Morales‐Lázaro, Sara L., Tiburcio‐Félix, Reynaldo, Ortega, Arturo, Magaña, Jonathan J, Winder, Steve J., Cisneros, Bulmaro
Format: Artigo
Idioma:Inglês
Publicat: John Wiley and Sons Inc. 2019
Matèries:
Original Articles
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6718587/
https://ncbi.nlm.nih.gov/pubmed/31305018
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/acel.13002
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