Enhanced nuclear protein export in premature aging and rescue of the progeria phenotype by modulation of CRM1 activity

The study of Hutchinson–Gilford progeria syndrome (HGPS) has provided important clues to decipher mechanisms underlying aging. Progerin, a mutant lamin A, disrupts nuclear envelope structure/function, with further impairment of multiple processes that culminate in senescence. Here, we demonstrate th...

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書誌詳細
出版年:Aging Cell
主要な著者: García‐Aguirre, Ian, Alamillo‐Iniesta, Alma, Rodríguez‐Pérez, Ruth, Vélez‐Aguilera, Griselda, Amaro‐Encarnación, Elianeth, Jiménez‐Gutiérrez, Elizabeth, Vásquez‐Limeta, Alejandra, Samuel Laredo‐Cisneros, Marco, Morales‐Lázaro, Sara L., Tiburcio‐Félix, Reynaldo, Ortega, Arturo, Magaña, Jonathan J, Winder, Steve J., Cisneros, Bulmaro
フォーマット: Artigo
言語:Inglês
出版事項: John Wiley and Sons Inc. 2019
主題:
Original Articles
オンライン･アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC6718587/
https://ncbi.nlm.nih.gov/pubmed/31305018
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/acel.13002
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