Pan-tumor genomic biomarkers for PD-1 checkpoint blockade–based immunotherapy

INTRODUCTION: Immunotherapy targeting the programmed cell death protein–1 (PD-1) axis elicits durable antitumor responses in multiple cancer types. However, clinical responses vary, and biomarkers predictive of response may help to identify patients who will derive the greatest therapeutic benefit....

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Vydáno v:Science
Hlavní autoři: Cristescu, Razvan, Mogg, Robin, Ayers, Mark, Albright, Andrew, Murphy, Erin, Yearley, Jennifer, Sher, Xinwei, Liu, Xiao Qiao, Lu, Hongchao, Nebozhyn, Michael, Zhang, Chunsheng, Lunceford, Jared K., Joe, Andrew, Cheng, Jonathan, Webber, Andrea L., Ibrahim, Nageatte, Plimack, Elizabeth R., Ott, Patrick A., Seiwert, Tanguy Y., Ribas, Antoni, McClanahan, Terrill K., Tomassini, Joanne E., Loboda, Andrey, Kaufman, David
Médium: Artigo
Jazyk:Inglês
Vydáno: 2018
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6718162/
https://ncbi.nlm.nih.gov/pubmed/30309915
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.aar3593
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