Pan-tumor genomic biomarkers for PD-1 checkpoint blockade–based immunotherapy

INTRODUCTION: Immunotherapy targeting the programmed cell death protein–1 (PD-1) axis elicits durable antitumor responses in multiple cancer types. However, clinical responses vary, and biomarkers predictive of response may help to identify patients who will derive the greatest therapeutic benefit....

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Publicado no:Science
Main Authors: Cristescu, Razvan, Mogg, Robin, Ayers, Mark, Albright, Andrew, Murphy, Erin, Yearley, Jennifer, Sher, Xinwei, Liu, Xiao Qiao, Lu, Hongchao, Nebozhyn, Michael, Zhang, Chunsheng, Lunceford, Jared K., Joe, Andrew, Cheng, Jonathan, Webber, Andrea L., Ibrahim, Nageatte, Plimack, Elizabeth R., Ott, Patrick A., Seiwert, Tanguy Y., Ribas, Antoni, McClanahan, Terrill K., Tomassini, Joanne E., Loboda, Andrey, Kaufman, David
Formato: Artigo
Idioma:Inglês
Publicado em: 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6718162/
https://ncbi.nlm.nih.gov/pubmed/30309915
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.aar3593
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