Pan-tumor genomic biomarkers for PD-1 checkpoint blockade–based immunotherapy

INTRODUCTION: Immunotherapy targeting the programmed cell death protein–1 (PD-1) axis elicits durable antitumor responses in multiple cancer types. However, clinical responses vary, and biomarkers predictive of response may help to identify patients who will derive the greatest therapeutic benefit....

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Опубликовано в: :Science
Главные авторы: Cristescu, Razvan, Mogg, Robin, Ayers, Mark, Albright, Andrew, Murphy, Erin, Yearley, Jennifer, Sher, Xinwei, Liu, Xiao Qiao, Lu, Hongchao, Nebozhyn, Michael, Zhang, Chunsheng, Lunceford, Jared K., Joe, Andrew, Cheng, Jonathan, Webber, Andrea L., Ibrahim, Nageatte, Plimack, Elizabeth R., Ott, Patrick A., Seiwert, Tanguy Y., Ribas, Antoni, McClanahan, Terrill K., Tomassini, Joanne E., Loboda, Andrey, Kaufman, David
Формат: Artigo
Язык:Inglês
Опубликовано: 2018
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Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC6718162/
https://ncbi.nlm.nih.gov/pubmed/30309915
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.aar3593
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