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Calpain-cleaved type 1 inositol 1,4,5-trisphosphate receptor impairs ER Ca(2+) buffering and causes neurodegeneration in primary cortical neurons

Disruption of neuronal Ca(2+) homeostasis plays a well-established role in cell death in a number of neurodegenerative disorders. Recent evidence suggests that proteolysis of the type 1 inositol 1,4,5-trisphosphate receptor (InsP R1), a Ca(2+) release channel on the endoplasmic reticulum, generates...

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Bibliografiske detaljer
Udgivet i:J Neurochem
Main Authors: Kopil, Catherine M., Siebert, Adam P., Foskettt, J. Kevin, Neumar, Robert W.
Format: Artigo
Sprog:Inglês
Udgivet: 2012
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6718092/
https://ncbi.nlm.nih.gov/pubmed/22762283
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1471-4159.2012.07859.x
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