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Calpain-cleaved type 1 inositol 1,4,5-trisphosphate receptor impairs ER Ca(2+) buffering and causes neurodegeneration in primary cortical neurons
Disruption of neuronal Ca(2+) homeostasis plays a well-established role in cell death in a number of neurodegenerative disorders. Recent evidence suggests that proteolysis of the type 1 inositol 1,4,5-trisphosphate receptor (InsP R1), a Ca(2+) release channel on the endoplasmic reticulum, generates...
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| 發表在: | J Neurochem |
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| Main Authors: | , , , |
| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
2012
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6718092/ https://ncbi.nlm.nih.gov/pubmed/22762283 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1471-4159.2012.07859.x |
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