Bcl-2 functionally interacts with inositol 1,4,5-trisphosphate receptors to regulate calcium release from the ER in response to inositol 1,4,5-trisphosphate

Inositol 1,4,5-trisphosphate (InsP(3)) receptors (InsP(3)Rs) are channels responsible for calcium release from the endoplasmic reticulum (ER). We show that the anti-apoptotic protein Bcl-2 (either wild type or selectively localized to the ER) significantly inhibited InsP(3)-mediated calcium release...

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Autori principali: Chen, Rui, Valencia, Ignacio, Zhong, Fei, McColl, Karen S., Roderick, H. Llewelyn, Bootman, Martin D., Berridge, Michael J., Conway, Stuart J., Holmes, Andrew B., Mignery, Gregory A., Velez, Patricio, Distelhorst, Clark W.
Natura: Artigo
Lingua:Inglês
Pubblicazione: The Rockefeller University Press 2004
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Research Articles
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2172311/
https://ncbi.nlm.nih.gov/pubmed/15263017
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.200309146
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