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Glucocorticoid-mediated Inhibition of Lck Modulates the Pattern of T Cell Receptor-induced Calcium Signals by Down-regulating Inositol 1,4,5-Trisphosphate Receptors

Glucocorticoids are potent immunosuppressive agents that block upstream signaling events required for T cell receptor (TCR) activation. However, the mechanism by which glucocorticoids inhibit downstream responses, such as inositol 1,4,5-trisphosphate (IP(3))-induced calcium signals, is not completel...

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Hlavní autoři: Harr, Michael W., Rong, Yiping, Bootman, Martin D., Roderick, H. Llewelyn, Distelhorst, Clark W.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2009
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2797257/
https://ncbi.nlm.nih.gov/pubmed/19776014
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.005579
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