Viral-mediated gene delivery of TMBIM6 protects the neonatal brain via disruption of NPR-CYP complex coupled with upregulation of Nrf-2 post-HI

BACKGROUND: Oxidative stress, inflammation, and endoplasmic reticulum (ER) stress play a major role in the pathogenesis of neonatal hypoxic-ischemic (HI) injury. ER stress results in the accumulation of unfolded proteins that trigger the NADPH-P450 reductase (NPR) and the microsomal monooxygenase sy...

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Bibliographic Details
Published in:J Neuroinflammation
Main Authors: Doycheva, Desislava, Xu, Ningbo, Tang, Jiping, Zhang, John
Format: Artigo
Language:Inglês
Published: BioMed Central 2019
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Research
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6717394/
https://ncbi.nlm.nih.gov/pubmed/31472686
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12974-019-1559-4
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