Adenoviral TMBIM6 vector attenuates ER-stress-induced apoptosis in a neonatal hypoxic-ischemic rat model

Endoplasmic reticulum (ER) stress is a major pathology encountered after hypoxic-ischemic (HI) injury. Accumulation of unfolded proteins triggers the unfolded protein response (UPR), resulting in the activation of pro-apoptotic cascades that lead to cell death. Here, we identified Bax inhibitor 1 (B...

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Publicat a:Dis Model Mech
Autors principals: Doycheva, Desislava, Xu, Ningbo, Kaur, Harpreet, Malaguit, Jay, McBride, Devin William, Tang, Jiping, Zhang, John H.
Format: Artigo
Idioma:Inglês
Publicat: The Company of Biologists Ltd 2019
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6898997/
https://ncbi.nlm.nih.gov/pubmed/31636086
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/dmm.040352
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