Penfluridol triggers cytoprotective autophagy and cellular apoptosis through ROS induction and activation of the PP2A-modulated MAPK pathway in acute myeloid leukemia with different FLT3 statuses

BACKGROUND: Chemotherapy is the main treatment for acute myeloid leukemia (AML), but the cure rates for AML patients remain low, and the notorious adverse effects of chemotherapeutic drugs drastically reduce the life quality of patients. Penfluridol, a long-acting oral antipsychotic drug, has an out...

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書目詳細資料
發表在:J Biomed Sci
Main Authors: Wu, Szu-Yuan, Wen, Yu-Ching, Ku, Chia-Chi, Yang, Yi-Chieh, Chow, Jyh-Ming, Yang, Shun-Fa, Lee, Wei-Jiunn, Chien, Ming-Hsien
格式: Artigo
語言:Inglês
出版: BioMed Central 2019
主題:
Research
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC6717358/
https://ncbi.nlm.nih.gov/pubmed/31470848
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12929-019-0557-2
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