Penfluridol triggers cytoprotective autophagy and cellular apoptosis through ROS induction and activation of the PP2A-modulated MAPK pathway in acute myeloid leukemia with different FLT3 statuses

BACKGROUND: Chemotherapy is the main treatment for acute myeloid leukemia (AML), but the cure rates for AML patients remain low, and the notorious adverse effects of chemotherapeutic drugs drastically reduce the life quality of patients. Penfluridol, a long-acting oral antipsychotic drug, has an out...

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Bibliographic Details
Published in:J Biomed Sci
Main Authors: Wu, Szu-Yuan, Wen, Yu-Ching, Ku, Chia-Chi, Yang, Yi-Chieh, Chow, Jyh-Ming, Yang, Shun-Fa, Lee, Wei-Jiunn, Chien, Ming-Hsien
Format: Artigo
Language:Inglês
Published: BioMed Central 2019
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Research
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6717358/
https://ncbi.nlm.nih.gov/pubmed/31470848
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12929-019-0557-2
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