The Curcumin Analogue, EF-24, Triggers p38 MAPK-Mediated Apoptotic Cell Death via Inducing PP2A-Modulated ERK Deactivation in Human Acute Myeloid Leukemia Cells

Curcumin (CUR) has a range of therapeutic benefits against cancers, but its poor solubility and low bioavailability limit its clinical use. Demethoxycurcumin (DMC) and diphenyl difluoroketone (EF-24) are natural and synthetic curcumin analogues, respectively, with better solubilities and higher anti...

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Bibliographic Details
Published in:Cancers (Basel)
Main Authors: Hsiao, Pei-Ching, Chang, Jer-Hwa, Lee, Wei-Jiunn, Ku, Chia-Chi, Tsai, Meng-Ying, Yang, Shun-Fa, Chien, Ming-Hsien
Format: Artigo
Language:Inglês
Published: MDPI 2020
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7464750/
https://ncbi.nlm.nih.gov/pubmed/32759757
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/cancers12082163
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