Second harmonic generation detection of Ras conformational changes and discovery of a small molecule binder

Second harmonic generation (SHG) is an emergent biophysical method that sensitively measures real-time conformational change of biomolecules in the presence of biological ligands and small molecules. This study describes the successful implementation of SHG as a primary screening platform to identif...

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Veröffentlicht in:Proc Natl Acad Sci U S A
Hauptverfasser: Donohue, Elizabeth, Khorsand, Sina, Mercado, Gabriel, Varney, Kristen M., Wilder, Paul T., Yu, Wenbo, MacKerell, Alexander D., Alexander, Patrick, Van, Que N., Moree, Ben, Stephen, Andrew G., Weber, David J., Salafsky, Joshua, McCormick, Frank
Format: Artigo
Sprache:Inglês
Veröffentlicht: National Academy of Sciences 2019
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PNAS Plus
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6717309/
https://ncbi.nlm.nih.gov/pubmed/31399543
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1905516116
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