Toxoplasma gondii effector TgIST blocks type I interferon signaling to promote infection

In contrast to the importance of type II interferon-γ (IFN-γ) in control of toxoplasmosis, the role of type I IFN is less clear. We demonstrate here that TgIST, a secreted effector previously implicated in blocking type II IFN-γ signaling, also blocked IFN-β responses by inhibiting STAT1/STAT2-media...

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Detaylı Bibliyografya
Yayımlandı:Proc Natl Acad Sci U S A
Asıl Yazarlar: Matta, Sumit K., Olias, Philipp, Huang, Zhou, Wang, Qiuling, Park, Eugene, Yokoyama, Wayne M., Sibley, L. David
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: National Academy of Sciences 2019
Konular:
Biological Sciences
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC6717281/
https://ncbi.nlm.nih.gov/pubmed/31413201
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1904637116
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