HuR counteracts miR-330 to promote STAT3 translation during inflammation-induced muscle wasting

Debilitating cancer-induced muscle wasting, a syndrome known as cachexia, is lethal. Here we report a posttranscriptional pathway involving the RNA-binding protein HuR as a key player in the onset of this syndrome. Under these conditions, HuR switches its function from a promoter of muscle fiber for...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Mubaid, Souad, Ma, Jennifer F., Omer, Amr, Ashour, Kholoud, Lian, Xian J., Sanchez, Brenda J., Robinson, Samantha, Cammas, Anne, Dormoy-Raclet, Virginie, Di Marco, Sergio, Chittur, Sridar V., Tenenbaum, Scott A., Gallouzi, Imed-Eddine
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2019
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PNAS Plus
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6717253/
https://ncbi.nlm.nih.gov/pubmed/31405989
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1905172116
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