NF-κB-Mediated MyoD Decay during Muscle Wasting Requires Nitric Oxide Synthase mRNA Stabilization, HuR Protein, and Nitric Oxide Release

Muscle wasting (cachexia) is a consequence of chronic diseases, such as cancer, and is associated with degradation of muscle proteins such as MyoD. The cytokines tumor necrosis factor alpha and gamma interferon induce muscle degeneration by activating the transcription factor NF-κB and its target ge...

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Autors principals: Di Marco, Sergio, Mazroui, Rachid, Dallaire, Patrice, Chittur, Sridar, Tenenbaum, Scott A., Radzioch, Danuta, Marette, Andre, Gallouzi, Imed-Eddine
Format: Artigo
Idioma:Inglês
Publicat: American Society for Microbiology 2005
Matèries:
Gene Expression
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC1190341/
https://ncbi.nlm.nih.gov/pubmed/16024790
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.25.15.6533-6545.2005
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