NF-κB-Mediated MyoD Decay during Muscle Wasting Requires Nitric Oxide Synthase mRNA Stabilization, HuR Protein, and Nitric Oxide Release

Muscle wasting (cachexia) is a consequence of chronic diseases, such as cancer, and is associated with degradation of muscle proteins such as MyoD. The cytokines tumor necrosis factor alpha and gamma interferon induce muscle degeneration by activating the transcription factor NF-κB and its target ge...

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Bibliographic Details
Main Authors: Di Marco, Sergio, Mazroui, Rachid, Dallaire, Patrice, Chittur, Sridar, Tenenbaum, Scott A., Radzioch, Danuta, Marette, Andre, Gallouzi, Imed-Eddine
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2005
Subjects:
Gene Expression
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC1190341/
https://ncbi.nlm.nih.gov/pubmed/16024790
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.25.15.6533-6545.2005
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