Lovastatin attenuates hypertension induced by renal tubule‐specific knockout of ATP‐binding cassette transporter A1, by inhibiting epithelial sodium channels

BACKGROUND AND PURPOSE: We have shown that cholesterol is synthesized in the principal cells of renal cortical collecting ducts (CCD) and stimulates the epithelial sodium channels (ENaC). Here we have determined whether lovastatin, a cholesterol synthesis inhibitor, can antagonize the hypertension i...

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Veröffentlicht in:Br J Pharmacol
Hauptverfasser: Wu, Ming‐Ming, Liang, Chen, Yu, Xiao‐Di, Song, Bin‐Lin, Yue, Qiang, Zhai, Yu‐Jia, Linck, Valerie, Cai, Yong‐Xu, Niu, Na, Yang, Xu, Zhang, Bao‐Long, Wang, Qiu‐Shi, Zou, Li, Zhang, Shuai, Thai, Tiffany L., Ma, Jing, Sutliff, Roy L., Zhang, Zhi‐Ren, Ma, He‐Ping
Format: Artigo
Sprache:Inglês
Veröffentlicht: John Wiley and Sons Inc. 2019
Schlagworte:
Research Papers
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6715779/
https://ncbi.nlm.nih.gov/pubmed/31222723
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bph.14775
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