Gut-derived GIP activates central Rap1 to impair neural leptin sensitivity during overnutrition

Nutrient excess, a major driver of obesity, diminishes hypothalamic responses to exogenously administered leptin, a critical hormone of energy balance. Here, we aimed to identify a physiological signal that arises from excess caloric intake and negatively controls hypothalamic leptin action. We foun...

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Detalhes bibliográficos
Publicado no:J Clin Invest
Main Authors: Kaneko, Kentaro, Fu, Yukiko, Lin, Hsiao-Yun, Cordonier, Elizabeth L., Mo, Qianxing, Gao, Yong, Yao, Ting, Naylor, Jacqueline, Howard, Victor, Saito, Kenji, Xu, Pingwen, Chen, Siyu S., Chen, Miao-Hsueh, Xu, Yong, Williams, Kevin W., Ravn, Peter, Fukuda, Makoto
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2019
Assuntos:
Concise Communication
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6715359/
https://ncbi.nlm.nih.gov/pubmed/31403469
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI126107
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