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Design and Use of Chikungunya Virus Replication Templates Utilizing Mammalian and Mosquito RNA Polymerase I-Mediated Transcription

Chikungunya virus (CHIKV) is a mosquito-borne alphavirus. It has a positive-sense RNA genome that also serves as the mRNA for four nonstructural proteins (nsPs) representing subunits of the viral replicase. Coupling of nsP and RNA synthesis complicates analysis of viral RNA replication. We developed...

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Detalhes bibliográficos
Publicado no:J Virol
Main Authors: Utt, Age, Rausalu, Kai, Jakobson, Madis, Männik, Andres, Alphey, Luke, Fragkoudis, Rennos, Merits, Andres
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2019
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6714806/
https://ncbi.nlm.nih.gov/pubmed/31217251
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00794-19
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