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A Chikungunya Virus trans-Replicase System Reveals the Importance of Delayed Nonstructural Polyprotein Processing for Efficient Replication Complex Formation in Mosquito Cells

Chikungunya virus (CHIKV) is a medically important alphavirus that is transmitted by Aedes aegypti and Aedes albopictus mosquitoes. The viral replicase complex consists of four nonstructural proteins (nsPs) expressed as a polyprotein precursor and encompasses all enzymatic activities required for vi...

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Detalhes bibliográficos
Publicado no:J Virol
Main Authors: Bartholomeeusen, Koen, Utt, Age, Coppens, Sandra, Rausalu, Kai, Vereecken, Katleen, Ariën, Kevin K., Merits, Andres
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2018
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6026725/
https://ncbi.nlm.nih.gov/pubmed/29695432
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00152-18
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