Mutations Conferring a Noncytotoxic Phenotype on Chikungunya Virus Replicons Compromise Enzymatic Properties of Nonstructural Protein 2

Chikungunya virus (CHIKV) (genus Alphavirus) has a positive-sense RNA genome. CHIKV nonstructural protein 2 (nsP2) proteolytically processes the viral nonstructural polyprotein, possesses nucleoside triphosphatase (NTPase), RNA triphosphatase, and RNA helicase activities, and induces cytopathic effe...

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Detalhes bibliográficos
Publicado no:J Virol
Main Authors: Utt, Age, Das, Pratyush Kumar, Varjak, Margus, Lulla, Valeria, Lulla, Aleksei, Merits, Andres
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2014
Assuntos:
Genome Replication and Regulation of Viral Gene Expression
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4337533/
https://ncbi.nlm.nih.gov/pubmed/25552719
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.03213-14
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