Proteasome Inhibition Activates Autophagy-Lysosome Pathway Associated With TFEB Dephosphorylation and Nuclear Translocation

Ubiquitin-proteasome pathway (UPS) and autophagy-lysosome pathway (ALP) are the two major protein degradation pathways, which are critical for proteostasis. Growing evidence indicates that proteasome inhibition-induced ALP activation is an adaptive response. Transcription Factor EB (TFEB) is a maste...

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Detalhes bibliográficos
Publicado no:Front Cell Dev Biol
Main Authors: Li, Chunyan, Wang, Xin, Li, Xuezhi, Qiu, Kaixin, Jiao, Fengjuan, Liu, Yidan, Kong, Qingxia, Liu, Yan, Wu, Yili
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2019
Assuntos:
Cell and Developmental Biology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6713995/
https://ncbi.nlm.nih.gov/pubmed/31508418
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fcell.2019.00170
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