Successful Brain Delivery of Andrographolide Loaded in Human Albumin Nanoparticles to TgCRND8 Mice, an Alzheimer’s Disease Mouse Model

Andrographolide (AG) was encapsulated in human albumin nanoparticles (AG NPs), and their crossing properties of the blood-brain barrier (BBB), brain distribution, and effects in TgCRND8 mice were evaluated. The development of appropriate NP formulations is mandatory because of the scarce BBB permeab...

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Publicat a:Front Pharmacol
Autors principals: Bilia, Anna Rita, Nardiello, Pamela, Piazzini, Vieri, Leri, Manuela, Bergonzi, Maria Camilla, Bucciantini, Monica, Casamenti, Fiorella
Format: Artigo
Idioma:Inglês
Publicat: Frontiers Media S.A. 2019
Matèries:
Pharmacology
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6713928/
https://ncbi.nlm.nih.gov/pubmed/31507412
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2019.00910
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