Influence of androgenic blockade with flutamide on pain behaviour and expression of the genes that encode the NaV1.7 and NaV1.8 voltage-dependent sodium channels in a rat model of postoperative pain

BACKGROUND: Experimental studies suggest that testosterone reduces the nociceptive response after inflammatory and neuropathic stimuli, however the underlying mechanisms have not been fully elucidated. The aims of this study were to evaluate the effect of peripheral blockade of testosterone on pain...

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Udgivet i:J Transl Med
Main Authors: Barbosa Neto, José Osvaldo, Garcia, João Batista Santos, Cartágenes, Maria do Socorro de Souza, Amaral, Andressa Godoy, Onuchic, Luiz Fernando, Ashmawi, Hazem Adel
Format: Artigo
Sprog:Inglês
Udgivet: BioMed Central 2019
Fag:
Research
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6712891/
https://ncbi.nlm.nih.gov/pubmed/31455381
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12967-019-2031-z
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