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Attenuation of autonomic reflexes by A803467 may not be solely caused by blockade of NaV 1.8 channels

In decerebrated rats, we determined the dose of A803467, a NaV 1.8 antagonist, needed to attenuate the reflex pressor responses to femoral arterial injections of lactic acid (24mM; ~0.1mL) and capsaicin (0.1μg), agents which stimulate thin fiber afferents having NaV 1.8 channels. We also determined...

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Detalhes bibliográficos
Main Authors: Stone, Audrey J., Kim, Joyce S., Yamauchi, Katsuya, Ruiz-Velasco, Victor, Kaufman, Marc P.
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3661189/
https://ncbi.nlm.nih.gov/pubmed/23523647
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neulet.2013.03.015
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