Systematic evaluation and validation of reference and library selection methods for deconvolution of cord blood DNA methylation data

BACKGROUND: Umbilical cord blood (UCB) is commonly used in epigenome-wide association studies of prenatal exposures. Accounting for cell type composition is critical in such studies as it reduces confounding due to the cell specificity of DNA methylation (DNAm). In the absence of cell sorting inform...

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Pubblicato in:Clin Epigenetics
Autori principali: Gervin, Kristina, Salas, Lucas A., Bakulski, Kelly M., van Zelm, Menno C., Koestler, Devin C., Wiencke, John K., Duijts, Liesbeth, Moll, Henriëtte A., Kelsey, Karl T., Kobor, Michael S., Lyle, Robert, Christensen, Brock C., Felix, Janine F., Jones, Meaghan J.
Natura: Artigo
Lingua:Inglês
Pubblicazione: BioMed Central 2019
Soggetti:
Methodology
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6712867/
https://ncbi.nlm.nih.gov/pubmed/31455416
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13148-019-0717-y
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