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Free-Energy Simulations Resolve the Low-Affinity Na(+)-High-Affinity Asp Binding Paradox in Glt(Ph)
Glutamate transporters clear up excess extracellular glutamate by cotransporting three Na(+) and one H(+) with the countertransport of one K(+). The archaeal homologs are selective to aspartate and only cotransport three Na(+). The crystal structures of Glt(Ph) from archaea have been used in computa...
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| Veröffentlicht in: | Biophys J |
|---|---|
| Hauptverfasser: | , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
The Biophysical Society
2019
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6712548/ https://ncbi.nlm.nih.gov/pubmed/31383357 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2019.07.016 |
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