Human T Cell Differentiation Negatively Regulates Telomerase Expression Resulting in Reduced Activation-Induced Proliferation and Survival

Maintenance of telomeres is essential for preserving T cell proliferative responses yet the precise role of telomerase in human T cell differentiation, function, and aging is not fully understood. Here we analyzed human telomerase reverse transcriptase (hTERT) expression and telomerase activity in s...

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Bibliographische Detailangaben
Veröffentlicht in:Front Immunol
Hauptverfasser: Patrick, Michael S., Cheng, Nai-Lin, Kim, Jaekwan, An, Jie, Dong, Fangyuan, Yang, Qian, Zou, Iris, Weng, Nan-ping
Format: Artigo
Sprache:Inglês
Veröffentlicht: Frontiers Media S.A. 2019
Schlagworte:
Immunology
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6712505/
https://ncbi.nlm.nih.gov/pubmed/31497023
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2019.01993
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