BET inhibitor JQ1 suppresses cell proliferation via inducing autophagy and activating LKB1/AMPK in bladder cancer cells

AIM: JQ1, a BET bromodomain inhibitor, is a promising therapeutic approach for bladder cancer (BC). Our study aimed to determine whether autophagy is induced by JQ1 and its potential role toward proliferation in BC. METHODS: Cell proliferation was determined by methylthiazolyldiphenyl‐tetrazolium br...

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Vydáno v:Cancer Med
Hlavní autoři: Li, Feng, Yang, Chao, Zhang, Hai‐Bao, Ma, Jianbin, Jia, Jing, Tang, Xiaoshuang, Zeng, Jin, Chong, Tie, Wang, Xinyang, He, Dalin, Guo, Peng
Médium: Artigo
Jazyk:Inglês
Vydáno: John Wiley and Sons Inc. 2019
Témata:
Cancer Biology
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6712466/
https://ncbi.nlm.nih.gov/pubmed/31250978
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cam4.2385
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