Clinicopathological and mutational analyses of colorectal cancer with mutations in the POLE gene

Here, we investigated the clinicopathological and mutation profiles of colorectal cancer (CRC) with POLE mutations. Whole‐exome sequencing was performed in 910 surgically resected primary CRCs. Tumors exceeding 500 counts of nonsynonymous single nucleotide variants (SNVs) were classified as hypermut...

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Detalhes bibliográficos
Publicado no:Cancer Med
Main Authors: Hino, Hitoshi, Shiomi, Akio, Kusuhara, Masatoshi, Kagawa, Hiroyasu, Yamakawa, Yushi, Hatakeyama, Keiichi, Kawabata, Takanori, Oishi, Takuma, Urakami, Kenichi, Nagashima, Takeshi, Kinugasa, Yusuke, Yamaguchi, Ken
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2019
Assuntos:
Clinical Cancer Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6712448/
https://ncbi.nlm.nih.gov/pubmed/31240875
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cam4.2344
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