Clinicopathological and mutational analyses of colorectal cancer with mutations in the POLE gene

Abstract Here, we investigated the clinicopathological and mutation profiles of colorectal cancer (CRC) with POLE mutations. Whole‐exome sequencing was performed in 910 surgically resected primary CRCs. Tumors exceeding 500 counts of nonsynonymous single nucleotide variants (SNVs) were classified as...

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Detaylı Bibliyografya
Asıl Yazarlar: Hitoshi Hino, Akio Shiomi, Masatoshi Kusuhara, Hiroyasu Kagawa, Yushi Yamakawa, Keiichi Hatakeyama, Takanori Kawabata, Takuma Oishi, Kenichi Urakami, Takeshi Nagashima, Yusuke Kinugasa, Ken Yamaguchi
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Wiley 2019-08-01
Seri Bilgileri:Cancer Medicine
Konular:
colorectal cancer
DNA polymerase epsilon gene
hypermutation
ultramutation
Online Erişim:https://doi.org/10.1002/cam4.2344
Etiketler: Etiketle
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